Chemical Studies on Japanese Coccidae. XVII

Free Radical Cyclizations, Xvii. Mechanistic Studies

Free radical cyclizations of the 4-phenylbutyl radical and analogues carrying naphthyl and vinyl groups instead of phenyl have been studied. A typical reaction scheme is given below involving closures to fiveand six-membered rings. Competition rate studies for the various types of ring closure were performed with deuterated analogues. The results can be used as an efficient mechanistic tool for...

Studies on Amphibian Metamorphosis Xvii. Influence of Non-living Annular Tympanic Cartilage on Tympanic Membrane Formation

INTRODUCTION THE tympanic membrane of the adult frog is divisible into three histologically distinct parts, viz. an inner epithelial layer, continuous with the mucous membrane of the tympanic cavity, the former being closely applied to a thin lamina propria conforming in shape and area to that of the annular tympanic cartilage to which it is attached at its peripheral borders. The third and out...

Chemical biology studies on norrisolide.

The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level of the Golgi. The Golgi localization and fragmentation effects of 7 depend on the presence of the perhydroindane core, while the irreversibility of ...

Chemical Studies on Sludge Digestion

Chemical Studies on Bacterial Agglutination

1. A method, conforming to the criteria of quantitative analytical chemistry, is described for the estimation of the agglutinin content of antisera. Examples are given of the application of the method to various antipneumococcus sera. 2. This new, absolute method is discussed with regard to its relation to the commonly used relative methods.